YES!!! I have a deviated septum and can never breathe out of one nostril. I recently got a cold and sure enough I'm breathing through my mouth, which makes my throat raw. I just tried this and it WORKS!! I can breathe through BOTH nostrils. I haven't been able to do that in years!! I only gave it 4 stars because the vapor in this burns the nostril a bit. I'm going to try the ones without the vapor. So happy though!